Source: Am J Clin Nutr, February 23, 2011;[Epub ahead of print]
Research: Thiamine, riboflavin, niacin, vitamin B-6, folate and vitamin B-12 are required to synthesize neurotransmitters that are potentially involved in the pathophysiology of premenstrual syndrome (PMS). In this study, researchers set out to evaluate whether B vitamin intake—from food sources and supplements—is associated with the initial development of PMS. They conducted a case-control study nested within the Nurses’ Health Study II cohort among participants who were free of PMS at baseline (1991). After 10 years of follow up, 1057 women were confirmed as cases and 1968 were confirmed as controls. Dietary information was collected in 1991, 1995 and 1999 by using food-frequency questionnaires.
Results: Intakes of thiamine and riboflavin from food sources were each inversely associated with incident PMS. For example, women in the highest quintile of riboflavin intake 2-4 years before the diagnosis year had a 35% lower risk of developing PMS than did those in the lowest quintile. However, there were no significant associations between incident PMS and dietary intakes of niacin, vitamin B-6, folate, and vitamin B-12. Additionally, intake of B vitamins from supplements was not associated with a lower risk of PMS.
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